Chloroprocaine use successfully for spinal anesthesia<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

傅润乔　赵宏利　薛绵荣　王大伟
徐　伟　阎红林　张晓红　金运敏
司　满　李树林
同济大学北京微创医院（筹），北京市垂杨柳医院麻醉医学中心，北京 100022

Run-qiao Fu, Hong-li Zhao, Mian-rong Xue, et al.
Center of Anesthesiology, Chui Yangliu Hospital, Beijing 100022, China

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ABSTRACT

　　Objective：To study possibility and safety of domestic chloroprocaine used for spinal anesthesia.

Method：40 primiparas were punctured from lumbar 2～3 spinal interspace and injected a 2.2ml mixture (2.5% chloroprocaine 1.2ml，10% glucose 0.5ml, 3% ephedrine 0.5ml) within 30～40 seconds into subarachnoid space.
　　Results：(1) Onset time, thoracic₁₁ pain-free time, time that lower limbs were unable to lift up, time of reaching to the highest nerve block level were, (22.78±9.52)sec，(3.65±0.86)min，(3.67±0.73)min and (8.04±1.11)min, respectively. The highest nerve block mean level were thoracic 4.05±1.38. Time of nerve block fade to thoracic₁₁, time of lower limbs were able to lift up and time of anesthesia complete disappearance were, (54.75±8.60)min, (68.63±13.22)min and (77.50±16.97)min, respectively.
　　(2) No one of primiparas complained surgery pain, and primiparas` abdominal muscles were relaxation.
　　(3) Hypotensions occur at mean time (5.21±1.67)min in 17 cases (17%) after anesthesia, and were effectively corrected by ephedrine.
　　(4) Nausea and vomiting were 22 (55%) cases, 12 (30%) associated to hypotension, and 16 (40%) respectively, during and operation.
　　(5) We could not observe any general and spinal nerve toxic responses.
　　(6) pH and density of 2.5% chloroprocaine were 6.38±0.55 and 1.012±0.003, respectively. pH and density of its spinal anesthesia mixture were 6.12±0.46 and 1.012±0.003, respectively.
　　Conclusions：2.5% chloroprocaine can safe and effective use for spinal anesthesia. Its pH value is larger than that in literatures published.
　　Key words：Chloroprocaine；Spinal anesthesia
　　Corresponding author：Run-qiao Fu,MD.phD; Runqiao@yahoo.com.cn

　　氯普鲁卡因用于蛛网膜下腔麻醉（腰麻）一直存在争议或被禁用。我们从2005年1月开始将其用于腰麻取得较好的效果，报告如下。

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