Page 13 - 麻醉与监护论坛2015年第3期

Cover Thesis
proET-1; 212 amino acids). After removal of the signal
sequence, it is further proteolytically processed at specific
basic residues leading to the production of bigET-1 (38
amino acids). ET-1 is finally excised from big ET-1 by the
action of endothelin-coverting enzyme .[10] In the present
study, we determined plasma proET-1 in septic patients.
The results showed that proET-1 levels in the unimproved
group were significantly higher than those in the healing
group (p<0.001). The level of proET-1 in plasma was
significantly correlated with the treatment efficacy, and
statistical tests showed there was a positive correlation
between them (p<0.001). Our results suggested that the
content of proET-1 in plasma varied with the clinical
efficacy. For the septic patients, many factors can affect
their clinical outcomes, but the fact that the infection
is under control is a key factor. In the present study,
we found that the infection score had the same change
because the healing group had the lowest proET-1 and
the unimproved group the highest, p<0.0001. Statistical
tests showed a significant difference between them and
there was also a positive correlation between the infection
score and treatment efficacy (p<0.0001). This indicated
that the infection score was also significantly associated
with the treatment efficacy. The results also showed that
the proET-1 level varied with the infection score since
statistical tests showed a positive correlation between
them, p<0.0001. The results of this study indicated that
proET-1 varied with infection score and the treatment
efficacy, both have a positive correlation with the
statistically significant difference. ProET-1 might be a
sensitive marker of infection in septic patients and could
be used for early diagnosis of severe infections. ProET-1
plasma levels increased with bacterial infection. Therefore
it can be taken as the early sign of infection and may help
to assess whether the patients are infected and the severity
of the infection, hence guiding the clinical practitioners
to monitor closely and to the appropriate treatment.
Quick and early diagnosis of sepsis is often difficult.
Because of the atypical clinical manifestations, low blood
Laboratory and Clinical CInovveesrtiTghaetisoins 21 FAM 2013 Jan/Feb Vol.20 Issue 1
culture positive rate and the possibility of a false positive,
CRP, a kind of acute phase protein, is commonly used
as a non-specific inflammatory index in clinical practice
.[11] It is valuable for the diagnosis of sepsis. However, it
also increases during viral infections, acute rejection and
surgical stress reaction, due to several influencing factors
in human bodies .[12] Therefore, it lacks the specificity for
the diagnosis of sepsis. The present study demonstrates the
value of proET-1 in the diagnosis of sepsis. In conclusion,
infection is an independent factor, which causes a change
in the proET-1 level in patients with sepsis. During the
infection process, plasma proET-1 levels significantly
increased and were significantly higher in the unimproved
group than in the healing group. ProET-1 level is valuable
in the early diagnosis of sepsis, indicating the effectiveness
of antibiotics and organ function support therapies
increasing the clinical success rate of salvage treatments in
patients with high risk factors.
Acknowledgement:
We thank Johannes Singer, Liwe Zing ler, Lutz
Schomburg, Chen Tao, Martin Burow (BRAHMS Institute,
Berlin, Germany) for their excellent technical assistance.
Declaration of Interest:
The authors declare no conflict of interest.
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